One of the key issues that divided Protestants and Roman Catholics during the Reformation was their understanding of Holy Scripture. In this monumental work, William Whitaker addresses six significant areas where Rome had deviated from the ancient and truly catholic understanding of the Bible. Interacting largely with two of Rome’s most formidable controversialists, Robert Bellarmine and Thomas Stapleton, Whitaker answers questions regarding the number of canonical books, the authentic editions and versions of Scripture, the authority of Scripture, the perspicuity of Scripture, the proper interpretation of Scripture, and the perfection of Scripture. Whitaker’s Disputation on Holy Scripture was an important rejoinder for Protestants in the sixteenth century and stands to this day as a worthy guide to God’s Word.